Evaluating next-generation sequencing (NGS) data requires an extensive knowledge of bioinformatics and programming commands, which could limit the studies in this area. We propose a user-friendly system to analyse raw NGS data from HIV-1 patient …
The pathway of human immunodeficiency virus (HIV) infection depends on the composition of a 35-amino acid variable region in its envelope, known as the V3 loop. Since this discovery, many tools have been developed to diagnose and predict viral …
The development of HIV coreceptor antagonists—such as maraviroc—has made coreceptor use diagnosis mandatory for each patient in the clinical setting. Technical issues presented by Trofile™, the gold standard phenotypic assay, hindered its use as a …
Bolsista de iniciação científica - Rita de Cássia Menezes Soares (Finalizado)
Bolsista de iniciação científica - Amanda Soares Rebelo de Lanna (Concluído)
Resistance to antiretrovirals (ARVs) is a major problem faced by HIV-infected individuals. Different rule-based algorithms were developed to infer HIV-1 susceptibility to antiretrovirals from genotypic data. However, there is discordance between …
Resistance to antiretroviral drugs has been a major obstacle for long-lasting treatment of HIV-infected patients. The development of models to predict drug resistance is recognized as useful for helping the decision of the best therapy for each HIV+ …
The development of models to predict the resistance to the antiretroviral drugs can be useful in making a decision regarding the best therapy for HIV+ individuals. This study developed predictive models of resistance to the protease inhibitor …
Resistance to antiretroviral drugs has been a major obstacle for a long-lasting treatment of HIV infected patients. The development of models to predict drug resistance is already recognized as useful for helping the decision making process regarding …
As lesões intraepiteliais escamosas de alto grau (HSIL) são precursoras do câncer do colo do útero, com maior risco de ocorrência e desenvolvimento em mulheres HIV+. Neste trabalho, estimamos e comparamos o desempenho do exame citológico e da captura …