Drug resistance

SIRA-HIV - A User-friendly System to Evaluate HIV-1 Drug Resistance from Next-generation Sequencing Data

Evaluating next-generation sequencing (NGS) data requires an extensive knowledge of bioinformatics and programming commands, which could limit the studies in this area. We propose a user-friendly system to analyse raw NGS data from HIV-1 patient …

Ensemble Classifiers for Predicting HIV-1 Resistance from Three Rule-Based Genotypic Resistance Interpretation Systems

Resistance to antiretrovirals (ARVs) is a major problem faced by HIV-infected individuals. Different rule-based algorithms were developed to infer HIV-1 susceptibility to antiretrovirals from genotypic data. However, there is discordance between …

Logistic Regression Models for Predicting Resistance to HIV Protease Inhibitor Nelfinavir

The development of models to predict the resistance to the antiretroviral drugs can be useful in making a decision regarding the best therapy for HIV+ individuals. This study developed predictive models of resistance to the protease inhibitor …